The methylome refers to the overall pattern of DNA methylation, an epigenetic modification that can affect gene expression, in a cell or tissue. DNA methylation involves the addition of a methyl group to the cytosine base of a DNA molecule, typically in a region called a CpG island, and can be influenced by a variety of genetic and environmental factors. Changes in the methylome have been associated with a range of health and disease states, including cancer, neurological and psychiatric disorders, and aging. Recent advances in sequencing and bioinformatics technologies have enabled a more comprehensive analysis of the methylome and may provide valuable insights into the molecular mechanisms underlying these conditions.