Giant spinal schwannoma

Giant spinal schwannomas are defined as intradural extramedullary spinal tumors that span >2 vertebral body lengths. Although uncommon, these lesions can cause significant mass effect on the spinal cord and subsequent neurologic compromise.

Gross total resection is the goal of operative intervention, however, is extremely challenging in cases where the tumor occupies a ventral, midline position within the lower cervical thecal sac.

Various approaches have been described for treating these tumors 1) 2) 3) 4) 5) 6) 7) 8) 9) 10).

Hussain et al. describe an adult male with insidious progression of upper extremity radicular pain and paresthesias, found to have a ventral, solid/cystic C5-C7 giant schwannoma. They demonstrate the step-by-step surgical technique for an anterior approach 2-level cervical corpectomy, microsurgical resection of an intradural giant schwannoma, watertight dural closure, and lastly 360-degrees instrumented stabilization of the cervicothoracic spine. In addition we incorporate the utilization of a portable intraoperative computed tomography for stereotactic localization and 3-dimensional navigation-guided screw implantation. Finally, we discuss various preoperative, perioperative, and postoperative considerations that can have profound impact on successful outcomes 11).


1)
Sridhar K, Ramamurthi R, Vasudevan MC, Ramamurthi B. Limited unilateral approach for extramedullary spinal tumours. Br J Neurosurg. 1998;12:430–433.
2)
Celli P, Trillo G, Ferrante L. Spinal extradural schwannoma. J Neurosurg Spine. 2005;2:447–456.
3)
Jinnai T, Koyama T. Clinical characteristics of spinal nerve sheath tumors: analysis of 149 cases. Neurosurgery. 2005;56:510–515.
4)
Singh DK, Singh N, Rastogi M, Husain M. The transparaspinal approach: A novel technique for one-step removal of dumb-bell-shaped spinal tumors. J Craniovertebr Junction Spine. 2011;2:96–98.
5)
Love JG, Dodge HW., Jr Dumbbell (hourglass) neurofibromas affecting the spinal cord. Surg Gynecol Obstet. 1952;94:161–172.
6)
Satoh N, Ueda Y, Koizumi M, et al. Assessment of pure single nerve root resection in the treatment of spinal schwannoma: focus on solitary spinal schwannomas located below the thoracolumbar junction. J Orthop Sci. 2011;16:148–155.
7)
Lu DC, Dhall SS, Mummaneni PV. Mini-open removal of extradural foraminal tumors of the lumbar spine. J Neurosurg Spine. 2009;10:46–50.
8)
Park SC, Chung SK, Choe G, Kim HJ. Spinal intraosseous schwannoma: a case report and review. J Korean Neurosurg Soc. 2009;46:403–408.
9)
Ozawa H, Kokubun S, Aizawa T, Hoshikawa T, Kawahara C. Spinal dumbbell tumors: an analysis of a series of 118 cases. J Neurosurg Spine. 2007;7:587–593.
10)
Sridhar K, Ramamurthi R, Vasudevan MC, Ramamurthi B. Giant invasive spinal schwannomas: definition and surgical management. J Neurosurg. 2001;94:210–215.
11)
Hussain I, Navarro-Ramirez R, Lang G, Härtl R. 3D Navigation-guided Resection of Giant Ventral Cervical Intradural Schwannoma With 360-Degree Stabilization. Clin Spine Surg. 2017 Feb 27. doi: 10.1097/BSD.0000000000000511. [Epub ahead of print] PubMed PMID: 28244892.
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