Epidermal growth factor receptor
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4).
EGFR is found on the surface of some normal cells and is involved in cell growth. It may also be found at high levels on some types of cancer cells, which causes these cells to grow and divide. Blocking EGFR may keep cancer cells from growing. Some epidermal growth factor receptor tyrosine kinase inhibitors are used to treat cancer. Also called EGFR inhibitor, EGFR tyrosine kinase inhibitor, and epidermal growth factor receptor inhibitor.
Preoperative assessment of epidermal growth factor receptor (EGFR) status, response to EGFR-tyrosine kinase inhibitors (TKI), and development of T790M mutation in non-small cell lung cancer (NSCLC) patients with brain metastases (BM) is essential for clinical decision-making, while previous studies were only based on the whole BM