Biochemical workup often documents several pituitary insufficiencies. In histopathology, the majority of NFPAs are gonadotroph
They mainly invade the sphenoid, cavernous sinus or dura mater.
Detection of a sellar mass by MRI. Biochemical testing can identify the adenoma cell type in those that are clinically silent.
Mean PRL in nonfunctioning pituitary neuroendocrine tumors was 39 ng/ml, with a majority of patients with stalk effect having PRL < 200 ng/ ml 1).
Immunohistochemical evaluation
Immunohistochemical evaluation has revealed that most of these lesions are of gonadotroph differentiation, as they usually immunostain for the beta subunit of LH and/or FSH, as well as for the common alpha subunit of these glycoproteic hormones; a small proportion of these patients have tumors that immunostain for ACTH, GH, and TSH, the so-called “silent corticotroph, somatotroph, and thyrotroph adenomas,” respectively 2) 3).