Christian Migliarese
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Relevance Analysis of Selected Research Articles
1. Combination Therapy of Adagrasib and Abemaciclib in NSCLC Brain Metastasis (KRAS-G12C, CDKN2A loss)
- Neurosurgery relevance:
'High'. Targets brain metastases; neurosurgeons must consider systemic options that affect surgical decisions. - Oncology relevance:
'Very high'. KRAS-G12C is a hot target; combination with CDK4/6 inhibition is cutting-edge. - Clinical impact: Personalization of therapy may delay or reduce the need for surgery or radiosurgery.
2. PTEN Potentiation of Oncolytic HSV Therapy for Glioblastoma
- Neurosurgery relevance:
'Very high'. Glioblastoma is a core concern in neurosurgical oncology; virotherapy may be integrated intraoperatively. - Oncology relevance:
'High'. Combines gene therapy and immunotherapy approaches in neuro-oncology. - Clinical impact: Preclinical but promising as adjunct to surgical resection.
Summary Table
| Article Title | Neurosurgery | Oncology | Clinical Practice |
|---|---|---|---|
| Combination Therapy in KRAS-G12C NSCLC Brain Mets | ★★★★☆ | ★★★★★ | ★★★★☆ |
| PTEN + Oncolytic HSV in Glioblastoma | ★★★★★ | ★★★★☆ | ★★★☆☆ |