cerebral_blood_volume

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Cerebral blood volume

Difference between Cerebral Blood Volume (CBV) and Cerebral Blood Volume Index (CBVI)

Feature Cerebral Blood Volume (CBV) Cerebral Blood Volume Index (CBVI)
Type Absolute Relative / Normalized
Units mL/100 g of brain tissue Unitless ratio or percentage
Definition Volume of blood within a given mass of brain tissue Normalized CBV relative to a reference region
Measurement Directly from perfusion imaging (CT or MRI) CBV in ROI divided by CBV in reference region (e.g. contralateral)
Normalization ❌ No normalization ✅ Normalized
Clinical Use Identifies ischemic core, tumor vascularity Enables inter-patient or inter-regional comparison
Example Use Case Low CBV = infarct core CBVI = 1.5 → 50% higher blood volume than reference tissue
Limitation Varies between individuals and brain regions Removes variability; standardizes interpretation

Summary

  • CBV is an absolute perfusion metric.
  • CBVI is a normalized or indexed version of CBV, designed to allow standardization across individuals or brain regions.
  • CBVI improves comparability, especially in clinical trials and multi-center studies involving perfusion imaging.

150 ml.

Quantitative measurement of cerebral blood volume (CBV, defined as ml blood in 100 ml brain) is useful for advancing our understanding of brain physiology and pathophysiology 1) 2).

Perfusion computed tomography (CT) is a technique that allows rapid qualitative and quantitative evaluation of cerebral perfusion by generating maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT).

see Relative cerebral blood volume.

Studies found significantly higher median CBV (p = 0.00003, ANOVA) and lower median ADC in contrast-enhancing areas of glioblastomas, compared to astrocytomas and oligodendrogliomas (p = 0.41333, ANOVA). Interestingly, molecularly defined glioblastoma, which usually does not contain contrast-enhancing areas, also shows significantly higher CBV values in the non-enhancing tumor than common glioblastoma and astrocytoma grade 4 (p = 0.01309, ANOVA).

Advanced imaging shows promise in visualizing tumor biology and improving the diagnosis of brain tumor patients 3)

1)
Derdeyn CP, Videen TO, Yundt KD, Fritsch SM, Carpenter DA, Grubb RL, Powers WJ. Variability of cerebral blood volume and oxygen extraction: stages of cerebral hemodynamic impairment revisited. Brain. 2002;125(Pt 3):595–607.
2)
Kavec M, Usenius JP, Tuunanen PI, Rissanen A, Kauppinen RA. Assessment of cerebral hemodynamics and oxygen extraction using dynamic susceptibility contrast and spin echo blood oxygenation level-dependent magnetic resonance imaging: applications to carotid stenosis patients. Neuroimage. 2004;22:258–267
3)
Griessmair M, Delbridge C, Ziegenfeuter J, Bernhardt D, Gempt J, Schmidt-Graf F, Kertels O, Thomas M, Meyer HS, Zimmer C, Meyer B, Combs SE, Yakushev I, Wiestler B, Metz MC. Imaging the WHO 2021 Brain Tumor Classification: Fully Automated Analysis of Imaging Features of Newly Diagnosed Gliomas. Cancers (Basel). 2023 Apr 18;15(8):2355. doi: 10.3390/cancers15082355. PMID: 37190283.
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