Centrum semiovale

The centrum semiovale is a mass of white matter, superior to the lateral ventricles/corpus callosum, present in each of the cerebral hemispheres under cerebral cortex.

It has a semi-oval shape and contains projection, commissural, and association fibers. Inferiorly these fibres are continuous with the corona radiata.

Centrum semiovale (along with the basal ganglia) are a typical site for perivascular spaces

Fewer centrum semiovale enlarged perivascular spaces may be a biomarker for idiopathic normal pressure hydrocephalus. This pattern may be caused by mechanical obstruction due to upward displacement of the brain leading to reduced glymphatic clearance ¹⁾.