CD63
CD63 is a transmembrane protein of the tetraspanin family commonly found in the membrane of extracellular vesicles, particularly exosomes. It is widely used as a biomarker for EV identification and isolation.
Structure and Function
- Four transmembrane domains
- Localized in late endosomes, lysosomes, and exosomes
- Involved in:
- Vesicle formation and trafficking
- Protein sorting
- Cell adhesion and immune modulation
In EV Engineering
CD63 is often used as a molecular scaffold for displaying functional tags or facilitating selective cargo loading in synthetic or engineered EVs, such as in the E-NoMi system.