Arachidonic Acid, the primary n-6FA in the brain, is metabolized by cyclooxygenase (COX) and lipoxygenase (LOX) enzymes to pro-inflammatory eicosanoids that enhance vascular permeability, increase local blood flow, increase infiltration of leukocytes, and enhance production of proinflammatory cytokines 1).
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Calder PC. Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients. Braz J Med Biol Res. 2003 Apr;36(4):433–446.