Angioma Alliance

Angioma Alliance definition of hemorrhage in cavernous malformations

Acute or subacute symptoms (any of: headache, seizure, impaired consciousness, or new/worsened focal neurological deficit referable to the anatomic location of the CM) accompanied by radiological, pathological, surgical, or (rarely) only cerebrospinal fluid evidence of recent extra- or intralesional hemorrhage.

This definition does not include either an increase in CM diameter without other evidence of recent hemorrhage, nor the presence of a hemosiderin halo.