11C methionine positron emission tomography
Tumor to normal tissue ratio (T/N ratio) on 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors.
Indications
Glioma
Recurrent brain tumors
The visual assessment showed no significant difference from quantitative assessment of MET-PET with a relevant cut-off value for the differentiation of recurrent brain tumors from radiation-induced necrosis 1).
Meningioma
Acromegaly
MET-PET is a sensitive technique for diagnosing persistent acromegaly and its coregistration with 3T MRI has demonstrated a better definition of the interface, extension and location of the lesion in the management of active postoperative acromegaly 2).
1)
Minamimoto R, Saginoya T, Kondo C, Tomura N, Ito K, Matsuo Y, Matsunaga S,
Shuto T, Akabane A, Miyata Y, Sakai S, Kubota K. Differentiation of Brain Tumor
Recurrence from Post-Radiotherapy Necrosis with 11C-Methionine PET: Visual
Assessment versus Quantitative Assessment. PLoS One. 2015 Jul 13;10(7):e0132515.
doi: 10.1371/journal.pone.0132515. eCollection 2015. PubMed PMID: 26167681;
PubMed Central PMCID: PMC4500444.
2)
Rodriguez-Barcelo S, Gutierrez-Cardo A, Dominguez-Paez M, Medina-Imbroda J,
Romero-Moreno L, Arraez-Sanchez M. Clinical Usefulness of Coregistered
11C-Methionine Pet/ 3t Mri at the Follow Up of Acromegaly. World Neurosurg. 2013
Nov 13. pii: S1878-8750(13)01431-9. doi: 10.1016/j.wneu.2013.11.011. [Epub ahead
of print] PubMed PMID: 24239736.