Venous outflow

Venous outflow has been examined as a potential descriptor of the etiology of various diseases such as migraines, tinnitus, multiple sclerosis, and Alzheimer’s disease 1) 2)

However, results were often discouraging, with the exception of idiopathic intracranial hypertension, where a model of functional coupling between intracranial pressure (ICP) and sagittal sinus pressure (SSP) has been produced 3).

1)
Zakaria MMA, Mikhael SY, Hussein AKA, El-Din RAS, El-Malak HWA, Hewedi IH, Nadim HS. Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufciency. Folia Neuropathol. 2017;55(1):49–59.
2)
Henry-Feugeas MC. Assessing cerebrovascular contribution to late dementia of the Alzheimer’s type: the role of combined hemodynamic and structural MR analysis. J Neurol Sci. 2009;283(1–2):44–8.
3)
Bateman GA. Association between arterial infow and venous outfow in idiopathic and secondary intracranial hypertension. J Clin Neurosci. 2006;13(5):550–6.