Tyrosine (Tyr or Y) or 4-hydroxyphenylalanine, is one of the 22 amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. Its codons are UAC and UAU. The word “tyrosine” is from the Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist Justus von Liebig in the protein casein from cheese.
It is called tyrosyl when referred to as a functional group or side chain. Tyrosine is a hydrophobic amino acid.
Phosphorylation of tyrosine residues by tyrosine kinases such as c-Abl has been reported to have a central role in neurodegeneration.
cerebrospinal fluid tyrosine.
With great interest, we read the article by Jimenez-Jimenez et al. entitled “Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson's Disease: review and meta-analysis.” published in the August 2020 issue of European Journal of Neurology1 . The study is of profound academic importance, and there are some points we would like to address 1).