Tipifarnib

FGF-2 has been reported to controls radioresistance through RhoB, whose farnesylated form modulates radioresistance in GBM. Ducassou et al. treated 27 patients of newly diagnosed GBM with tipifarnib in continuous administration with RT starting 1 week before the initiation of radiation and TMZ was delivered at progression. Median OS was 80.3 weeks and median time to progression was 18.1 weeks. The study found FGF receptor-1 over-expression and avb3 as a negative prognostic factor ¹⁾.