The SW1573 cell line is derived from a human non-small cell lung carcinoma (NSCLC), specifically an adenocarcinoma. It is commonly used in cancer research to investigate drug resistance, tumor progression, and gene expression profiles.
Origin
Species: Homo sapiens (Human)
Tissue: Lung
Disease: Adenocarcinoma
Histology: Non-small cell lung cancer (NSCLC)
Characteristics
Morphology: Epithelial
Doubling time: ~24–36 hours
Growth properties: Adherent
Tumorigenic in mice: Yes (in immunocompromised mice)
EGFR status: Wild-type (often used in contrast to mutant EGFR models)
Applications
Study of chemoresistance, especially to cisplatin and paclitaxel
Research on apoptosis and cell cycle regulation
Gene expression profiling in NSCLC
Used as a comparator cell line in targeted therapy studies
Culture Conditions
Medium: RPMI-1640 supplemented with 10% fetal bovine serum (FBS)