🧬 SSTR1 (Somatostatin Receptor 1)

neuropeptide receptor sstr1 somatostatin glioblastoma

SSTR1 is one of five G-protein-coupled somatostatin receptors involved in neurotransmission, hormone regulation, and tumor biology.

🔹 1. Gene and Expression

Gene: SSTR1
Location: Chromosome 14q13
Expression:
- Brain (especially cortex, hippocampus)
- Pancreas, GI tract, pituitary
- Downregulated in glioblastoma

🔹 2. Function

Gi/o-coupled receptor → ↓cAMP
Inhibits hormone secretion (e.g., GH, insulin)
CNS: modulates synaptic activity, neuroprotection
Antiproliferative and antiangiogenic effects

🔹 3. Clinical Relevance

↓ SSTR1 in glioblastoma = poor prognosis
Correlates with:
- IDH1-wildtype
- EGFR amplification
- G-CIMP-negative subtype
May serve as a prognostic biomarker

💊 4. Therapeutic Implications

Agonists: octreotide, pasireotide
- ↓ proliferation in GBM cell lines
Potential strategies:
- Targeted therapy with SSTR1 agonists
- Combined molecular profiling + treatment

🔬 5. Ligands and Pathways

Type	Example	Function
Agonist	Octreotide	↓ tumor cell growth
Agonist	Pasireotide	Broader affinity (SSTR1/2/5)
Antagonist	(under study)	Not clinically available

Signaling Pathways Affected:

↓ Adenylyl cyclase → ↓ cAMP
CDKN1A-B upregulation
Modulation of JAK/STAT, NF-κB, TGF-β pathways

—- 📄 G-García et al. (2025) – Full article