The neuroprotection effects of simvastatin on the pre-existing hypercholesterolemia during TBI in rats may be related to its anti-neuroinflammatory effects but not to its cholesterol-lowing effects 1).
A meta-analysis 2) and multicenter randomized phase 3 trial of simvastatin 3) found no clinical benefit for aneurysmal subarachnoid hemorrhage.
It is a statin that could attenuate cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
Simvastatin combined with an antioxidant could provide neuroprotection and it may be attributed to a dampening of cerebral vascular endothelial inflammatory response. 4).