Salmonella focal intracranial infections are reported rarely. They tend to occur in immunocompromised patients.

A case of Salmonella typhimurium epidural empyema, with osteomyelitis of the adjacent frontal bone, in a 37-year-old human immunodeficiency virus positive man who presented with a three-day history of headache, fever, and sweats, was treated successfully with antibiotics and surgical drainage ¹⁾.