ROCK inhibitor

• ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease
• Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis
• Advanced imaging characterization of post-chemoradiation glioblastoma stratified by diffusion MRI phenotypes known to predict favorable anti-VEGF response
• Genetic Insights Into Hemorrhagic Stroke and Vascular Malformations: Pathogenesis and Emerging Therapeutic Strategies
• Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration
• The potential role of RhoA/ROCK-inhibition on locomotor recovery after spinal cord injury: a systematic review of in-vivo studies
• In Vitro Experiment Present ROCK2 Inhibition Promotes the Therapeutic Effect of Bevacizumab in the Treatment of Glioblastoma Multiforme
• Neoadjuvant anti-PD1 immunotherapy for surgically accessible recurrent glioblastoma: clinical and molecular outcomes of a stage 2 single-arm expansion cohort

### ROCK Inhibitors: Overview and Applications

#### 1. What are ROCK Inhibitors? ROCK inhibitors are pharmacological agents that block the activity of Rho-associated protein kinase (ROCK), a key enzyme in the RhoA/ROCK signaling pathway. These inhibitors reduce actin-myosin contractility, influencing various cellular processes like migration, proliferation, and adhesion.

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#### 2. Mechanism of Action ROCK inhibitors prevent the phosphorylation of: - Myosin Light Chain (MLC): Reduces actin-myosin contraction. - LIM Kinase (LIMK): Affects actin stability. - Adhesion Proteins: Modulate cellular stiffness and motility.

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#### 3. Common ROCK Inhibitors

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#### 4. Clinical Applications - Cardiovascular Diseases:

1. Hypertension: ROCK inhibitors reduce vascular resistance and blood pressure.
2. Pulmonary Hypertension: Improve arterial function by relaxing smooth muscle.

- Neurological Disorders:

1. Stroke: Enhance neuroprotection and axonal regeneration.
2. Spinal Cord Injury: Promote axon growth and functional recovery.see ROCK inhibitor for spinal cord injury

1. Neurodegenerative Diseases: Potential benefits in Parkinson’s and Alzheimer’s.

- Ophthalmology:

1. Glaucoma: Ripasudil improves aqueous humor outflow, reducing intraocular pressure.

- Oncology:

1. Cancer Metastasis: Reduce tumor cell migration and invasion.

- Fibrosis:

1. Lung, Liver, and Kidney Fibrosis: Decrease fibroblast activation and extracellular matrix deposition.

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#### 5. Emerging Research - Development of selective ROCK2 inhibitors to minimize side effects. - Combination therapies with ROCK inhibitors for enhanced efficacy in oncology and neurological diseases.