Refractory status epilepticus treatment

• Ketamine in Status Epilepticus: How Soon Is Now?
• Unveiling the Psychiatric and Neurological Manifestations of Idiopathic Hypoparathyroidism: A Case of Auditory Hallucinations and Seizure Disorder
• Atypical Cause of Autoimmune Encephalitis: The Role of Mycoplasma pneumoniae in Status Epilepticus
• Perampanel as a second-line therapy to midazolam reduces soman-induced status epilepticus and neurodegeneration in rats
• A single-center retrospective analysis of autoimmune glial fibrillary acidic protein astrocytopathy with seizures in children
• Optimizing vagus nerve stimulation for Super Refractory Status Epilepticus: A case series and systematic review
• Efficacy and Safety Study of the Revised Ege Pediatric Status Epilepticus Protocol (r-EPSEP)
• Convulsive status epilepticus revealing cerebral microbleeds in a pediatric patient: A rare case report

The treatment protocol for refractory status epilepticus is intensive and includes benzodiazepines, anticonvulsants, and eventually anesthetics for induced coma when polypharmacy is exhausted ¹⁾.

If seizures continue or recur after 24 hours following treatment with anesthetics, it is termed super refractory status epilepticus (SRSE). Because of high mortality with polypharmacy and continuous anesthetic use, there has been a great interest to use nonmedicinal devices like VNS ²⁾.

Vagus nerve stimulation for refractory status epilepticus treatment