RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene.
24 patients bearing large Somatotroph adenomas.
Clinical data and somatostatin receptor ligands (SRLs). SRLs response both before and after surgical debulking were collected and 21 molecular biomarkers of SRLs response were studied in tumor samples by gene expression.
From the 21 molecular markers studied, only two of them predicted enhanced SRLs response after surgery. Tumors with improved response to SRLs after surgical debulking showed lower levels of Ki-67 (MKI67, FC=0.17, and p=0.008) and higher levels of RAR-related orphan receptor C (RORC) (FC=3.1 and p˂0.001). When a cut-off of no detectable expression was used for Ki-67, the model provided a sensitivity of 100% and a specificity of 52.6% with an area under the curve of 65.8%. Using a cut-off of 2 units of relative expression of RORC, the prediction model showed 100% of sensitivity and specificity.
High levels of RAR-related orphan receptor C (RORC) and low levels of Ki-67 identify improved SRLs response after surgical debulking in large somatotroph adenomas. To determine their expression would facilitate medical treatment decision making after surgery 1).