Table of Contents

Primary central nervous system lymphoma chemotherapy

General information

For Primary central nervous system lymphoma:

In non-AIDS cases, chemotherapy combined with XRT prolongs survival compared to XRT alone. 1).

Methotrexate (MTX)

see Methotrexate for primary central nervous system lymphoma.

Rituximab

Rituximab is available since 1997 for the treatment of refractory systemic B-cell non-Hodgkin lymphoma. Intrathecally may be more effective for CD33 + lymphomas.

1)
DeAngelis LM, Yahalom J, Heinemann M-H, et al. Primary Central Nervous System Lymphomas: Combined Treatment with Chemotherapy and Radiotherapy. Neurology. 1990; 40:80–86