A practice-changing meta-analysis is a type of high-impact systematic review that synthesizes existing evidence across multiple studies in a way that significantly alters clinical practice guidelines or decision-making. These meta-analyses often:
Aggregate high-quality data (often from randomized controlled trials).
Provide statistically robust findings that clarify uncertainties in previous literature.
Challenge or confirm standard-of-care treatments.
Prompt updates in clinical guidelines from major health organizations.
Lead to measurable changes in how clinicians treat patients.
Example Characteristics: Large effect size with narrow confidence intervals.
Clear superiority or inferiority of an intervention.
Implications for safety, cost, or mortality.
Published in high-impact journals (e.g., NEJM, The Lancet, JAMA).
Real-World Examples: DARE meta-analysis (2005): Changed the way beta-blockers are used in heart failure.
Mammography screening meta-analyses: Influenced guidelines on the age and frequency of breast cancer screening.
Meta-analyses of thrombectomy in acute stroke: Changed stroke management worldwide.