Almost all patients have hydrocephalus by the time of presentation, causing typical signs and symptoms of headache, vomiting, lethargy, memory disturbance, abnormally increasing head circumference in infants, and seizures.
Parinaud’s syndrome, or sylvian aqueduct syndrome, may be present.
Precocious puberty may occur only in boys with choriocarcinomas or germinomas with syncytiotrophoblastic cells, due to luteinizing hormone-like effects of β-hCG secreted in the CSF.
Suprasellar germ cell tumor: triad of diabetes insipidus, visual deficit, and panhypopituitarism.
Drop metastases from CSF seeding can produce radiculopathy and/or myelopathy.