NADH stands for “nicotinamide adenine dinucleotide (NAD) + hydrogen (H).” It occurs naturally in the body and plays a role in generating energy. The NADH produced by the body is involved in making energy in the body. Taking NADH supplements might affect blood pressure and have other effects.
Mutations in isocitrate dehydrogenase (IDH) 1 & 2 genes reduce the enzymatic capacity of their coded proteins to bind their substrate, isocitrate, and convert it into α-ketoglutarate (α-KG), generating carbon dioxide and replenishing NADH and NADPH as side products 1)