The locus coeruleus, also spelled locus caeruleus or locus ceruleus is a nucleus in the pons (part of the brainstem) involved with physiological responses to stress and panic.
The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system.
Norepinephrine may also be released directly into the blood from the adrenal medulla.
Locus coeruleus syndrome as a complication of tectal surgery 1)