A close monitoring of liver function tests is recommended during treatment with temozolomide 1) 2) 3)

1)
Grieco A, Tafuri MA, Biolato M, Diletto B, Di Napoli N, Balducci N, Vecchio FM, Miele L. Severe cholestatic hepatitis due to temozolomide: an adverse drug effect to keep in mind. Case report and review of literature. Medicine (Baltimore). 2015 Mar;94(12):e476. doi: 10.1097/MD.0000000000000476. PMID: 25816026; PMCID: PMC4554001.
2)
Niewald M, Berdel C, Fleckenstein J, Licht N, Ketter R, Rübe C. Toxicity after radiochemotherapy for glioblastoma using temozolomide–a retrospective evaluation. Radiat Oncol. 2011 Oct 21;6:141. doi: 10.1186/1748-717X-6-141. PMID: 22017800; PMCID: PMC3213071.
3)
Goldbecker A, Tryc AB, Raab P, Worthmann H, Herrmann J, Weissenborn K. Hepatic encephalopathy after treatment with temozolomide. J Neurooncol. 2011 May;103(1):163-6. doi: 10.1007/s11060-010-0354-y. Epub 2010 Aug 22. PMID: 20730617.