Table of Contents

Hypoglossal nerve palsy

Hypoglossal nerve (cranial nerve XII) palsy is uncommon.

Etiology

Gamma Knife surgery for jugular foramen schwannoma 1).

see Hypoglossal nerve palsy due to internal carotid artery dissection.

Hypoglossal nerve palsy in a case of spontaneous atlantooccipital dislocation 2).

After carotid endarterectomy.

Isolated paralysis of the hypoglossal nerve due to atlanto-occipital joint cysts 3).

Clinical

Damage to this nerve produces characteristic clinical manifestations, of which unilateral atrophy of the tongue musculature is the most important.

Diagnosis

When clinical features are recognized, the radiologist, armed with the knowledge of the normal anatomy of the area, can focus on each segment of the nerve in search of a cause.

The hypoglossal nerve is divided into five segments: the medullary, cisternal, skull base, nasopharyngeal/oropharyngeal carotid space, and sublingual segments. Because each segment is usually affected by different disorders, localizing a lesion to a particular segment allows the radiologist to narrow the differential diagnosis. In this way, the most efficient imaging strategy for evaluation of the symptoms can be developed. Both computed tomography and magnetic resonance imaging are useful in assessing dysfunction of the hypoglossal nerve; the choice depends on the status of the patient and the preference of the radiologist 4).

1)
Hasegawa T, Kato T, Kida Y, Sasaki A, Iwai Y, Kondoh T, Tsugawa T, Sato M, Sato M, Nagano O, Nakaya K, Nakazaki K, Kano T, Hasui K, Nagatomo Y, Yasuda S, Moriki A, Serizawa T, Osano S, Inoue A. Gamma Knife surgery for patients with jugular foramen schwannomas: a multiinstitutional retrospective study in Japan. J Neurosurg. 2016 Jan 22:1-10. [Epub ahead of print] PubMed PMID: 26799304.
2)
Uppar AM, Pruthi N. Hypoglossal nerve palsy in a case of spontaneous atlanto-occipital dislocation - a rare clinical finding in a rare clinical entity. And its complete recovery following corrective surgery. World Neurosurg. 2020 Jan 25. pii: S1878-8750(20)30139-X. doi: 10.1016/j.wneu.2020.01.121. [Epub ahead of print] PubMed PMID: 31991230.
3)
Flores-Justa A, Santin-Amo JM, Sesar A, Roman-Pena P, Frieiro-Dantas C, Serramito-Garcia R, Raposo-Furelos M, Menendez-Cortezon B. Paralisis aislada del nervio hipogloso ocasionada por quistes occipitoatloideos [Isolated paralysis of the hypoglossal nerve due to atlanto-occipital joint cysts]. Rev Neurol. 2019 Jul 16;69(2):87-88. Spanish. doi: 10.33588/rn.6902.2019017. PMID: 31287152.
4)
Thompson EO, Smoker WR. Hypoglossal nerve palsy: a segmental approach. Radiographics. 1994 Sep;14(5):939-58. PubMed PMID: 7991825.