The current evidence suggests that HTS is as effective as mannitol at reducing raised ICP in aSAH. However, there is not enough data to recommend the optimal and safest dose concentration or whether HTS significantly improves outcomes in aSAH 1).

1)
Pasarikovski CR, Alotaibi NM, Al-Mufti F, Macdonald RL. Hypertonic Saline for Raised Intracranial Pressure Following Aneurysmal Subarachnoid Hemorrhage: A Systematic Review. World Neurosurg. 2017 May 23. pii: S1878-8750(17)30784-2. doi: 10.1016/j.wneu.2017.05.085. [Epub ahead of print] Review. PubMed PMID: 28549643.