| Grade | Tumor Types | Key Features |
|---|---|---|
| Grade 3 | - Anaplastic astrocytoma - Anaplastic oligodendroglioma | - High cellularity - Mitotic activity - No necrosis |
| Grade 4 | - Glioblastoma (GBM) - Diffuse midline glioma, H3 K27-altered | - Necrosis - Microvascular proliferation - Often IDH-wildtype - Very poor prognosis |
● Astrocytoma IDH-mutant Grade 3
● Astrocytoma IDH-mutant Grade 4
Anaplastic astrocytoma with mutations in the IDH gene.
Anaplastic oligodendroglioma, IDH-mutant & 1p/19q-codeleted
Diffuse midline glioma H3 K27-altered
see also Glioma classification
The term malignant or High-grade glioma refers to tumors that are classified as:
Anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, anaplastic ependymoma