There are limited data on the safety of fondaparinux for Venous thromboembolic prophylaxis VTE prophylaxis in ischemic stroke.

Fondaparinux is not associated with increased hemorrhagic complications compared with Unfractionated heparin (UFH) in patients with ischemic stroke. There were low rates of symptomatic VTE in both groups 1).

1)
Hackett CT, Ramanathan RS, Malhotra K, Quigley MR, Kelly KM, Tian M, Protetch J, Wong C, Wright DG, Tayal AH. Safety of venous thromboembolism prophylaxis with fondaparinux in ischemic stroke. Thromb Res. 2015 Feb;135(2):249-54. doi: 10.1016/j.thromres.2014.11.041. Epub 2014 Dec 13. PubMed PMID: 25554497.