Dalteparin (Fragmin®) or ardeparin (Normiflo®): 1 mg of protamine for every 100 anti-Xa IU of the LMWH (maximum dose = 50 mg) with a second infusion of 0.5 mg protamine for every 100 anti- Xa IU of LMWH if the APTT remains elevated 2–4 hours after the first dose is completed.