Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.

The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia.

The expression of CIRP in pituitary neuroendocrine tumor is closely related with tumor proliferation and invasion, and its significantly elevated expression level indicates post-op recurrence.