The severity and the duration of tissue hypoperfusion determine the fate of the ischemic tissue.

Neurogenesis in the cerebral infarction after an ischemic event is important to the rehabilitation of patients.

RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with silent cerebral infarction (SCI). and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA2/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI 1).

1)
Chen D, Huang X, Lu S, Deng H, Gan H, Du X, Weixue T. RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction. Exp Clin Endocrinol Diabetes. 2017 Jul 13. doi: 10.1055/s-0043-109099. [Epub ahead of print] PubMed PMID: 28704853.