Central hypothyroidism refers to thyroid hormone deficiency due to a disorder of the pituitary, hypothalamus, or hypothalamic-pituitary portal circulation, resulting in diminished thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH), or both.
Aqueductal stenosis in adulthood.
The most frequent cause of central hypothyroidism (CeH) is pituitary neuroendocrine tumors, but the mechanisms remain unclear.