The CD147 protein is a ubiquitous multifunctional membrane receptor. Expression of CD147, which is regulated by sterol carrier protein, reportedly modulates amyloid beta (Aβ), the neurotoxic peptide implicated in neuronal degeneration in Alzheimer disease (AD).
In glioma, temozolomide resistance is due to overexpression of CD147 protein and induction of Nuclear factor-erythroid 2 related factor 2 1)
Findings reveal potentially important relationships between cholesterol loading, CD147 expression, Aβ toxicity, and the putative involvement of CYPA protein in neuroprotection in AD 2).