see ACST.
see ACAS.
CEA reduces ipsilateral neurologic events but did not reduce the rate of ipsilateral strokes nor death (most deaths were secondary to MI). This trial did not include women and was not powered to detect differences in outcome subgroups.
No difference in outcome between CEA vs. aspirin (new stroke or death), but an unusual protocol lessened its statistical validity.
There were no major strokes or deaths in either the medical or the endarterectomy group. Surgically treated patients were not given aspirin, and 26% had an MI compared to 9% in the aspirin- treated medical arm, reflecting the high incidence of concomitant CAD in patients with an asympto- matic carotid artery stenosis.