Aquaporin 3 (AQP3)

Aquaporin 3 (AQP3) is a member of the aquaglyceroporin subfamily, meaning it facilitates the transport of both water and glycerol across cell membranes.

• 🧴 Skin – Keratinocytes in the epidermis
• 💧 Kidneys – Basolateral membrane of collecting ducts
• 🌬️ Respiratory tract
• 🧠 Digestive and immune systems

• Maintains skin hydration and elasticity
• Supports kidney water and solute reabsorption
• Involved in wound healing and inflammation
• Participates in cell migration and proliferation

• 🔻 Decreased AQP3 linked to:
  • Dry skin
  • Eczema
  • Impaired wound healing
• 🔺 Increased AQP3 seen in:
  • Certain cancers (gastric, prostate, colon)
  • Promotes tumor cell migration

• Wikipedia: Aquaporin 3
• AQP3 in Skin Physiology – NCBI