Acetazolamide for hydrocephalus treatment

Acetazolamide lowers ICP directly via its ability to reduce the choroid plexus CSF secretion, irrespective of the mode of drug administration 1)

The combination of Decadron, Diamox, and Zantac is a novel treatment for ventricular shunt failure that may temporarily improve symptoms in patients awaiting shunt revision. Future studies could compare efficacy with other medical treatments 2).

1)
Barbuskaite D, Oernbo EK, Wardman JH, Toft-Bertelsen TL, Conti E, Andreassen SN, Gerkau NJ, Rose CR, MacAulay N. Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus. Fluids Barriers CNS. 2022 Jun 29;19(1):53. doi: 10.1186/s12987-022-00348-6. PMID: 35768824; PMCID: PMC9245291.
2)
Lang SS, Ploof J, Atkin NJ, Tran-Du K, Kanuga BM, Storm PB, Heuer G, Yuan I, Abend NS, Kirschen MP, Topjian AA, Li Y, Waanders AJ, Zorc JJ, Huh JW. Decadron, Diamox, and Zantac: A Novel Combination for Ventricular Shunt Failure in Pediatric Neurosurgical Patients. Pediatr Emerg Care. 2021 Dec 1;37(12):e1444-e1450. doi: 10.1097/PEC.0000000000002070. PMID: 32195984.