Tumor to normal tissue ratio (T/N ratio) on 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors.
The visual assessment showed no significant difference from quantitative assessment of MET-PET with a relevant cut-off value for the differentiation of recurrent brain tumors from radiation-induced necrosis 1).
MET-PET is a sensitive technique for diagnosing persistent acromegaly and its coregistration with 3T MRI has demonstrated a better definition of the interface, extension and location of the lesion in the management of active postoperative acromegaly 2).