====== Xist ======


Xist is a non-coding RNA on the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. It is a component of the Xic – X-chromosome inactivation center – along with two other RNA genes and two protein genes.
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Lan et al. is committed to exploring the diagnostic and prognostic value of serum exosomal XIST secreted by tumour cells to predict recurrence in patients with triple-negative breast cancer (TNBC). Significant increments in XIST and Exo-XIST from tumor tissues and blood serum were found in reoccurring TNBC patients by comparison with non-recurrences. Levels of serum exo-XIST were only significantly increased in TNBC recurrence and no association with other clinicopathological parameters. Additionally, serum Exo-XIST levels could be served as an assessment of change in a load of triple-negative breast cancer. Expressions of Exo-XIST were markedly decreased after resection of the primary breast tumours and obviously elevated at the time of recurrence. Finally, an obvious association was identified between serum exo-XIST levels and poorer overall survival (OS) in TNBC patients. Levels of serum Exo-XIST may serve as a diagnostic and prognostic biomarker to predict the recurrent TNBC-loading status
((Lan F, Zhang X, Li H, Yue X, Sun Q. Serum exosomal lncRNA XIST is a potential non-invasive biomarker to diagnose recurrence of triple-negative breast cancer. J Cell Mol Med. 2021 May 5. doi: 10.1111/jcmm.16009. Epub ahead of print. PMID: 33949761.)).