====== Wuhan ======

[[COVID-19]] is a serious [[infection]] that originated in Wuhan, China, and has resulted in worldwide [[morbidity]] and mortality. It continues to be a major health concern in [[2022]], being associated with multiorgan failure. Although the [[pathophysiology]] of the disease and its complications are not well understood, it is believed that a [[cytokine]] storm, triggered by [[complement activation]] may be responsible for the severity and complications of the disease. As of now, there is no definitive treatment available. Hematological changes associated with COVID-19 include [[lymphopenia]], [[anemia]], [[thrombocytopenia]], [[disseminated intravascular coagulation]], and [[thrombosis]]. [[Paroxysmal nocturnal hemoglobinuria]] (PNH), on the other hand, is an acquired clonal hematopoietic stem cell disorder that occurs due to an acquired PIG-A mutation affecting the hematopoietic stem cells. Interestingly, PNH exhibits some clinical and laboratory manifestations like those seen in COVID-19. 
Albalawi et al. present a rare case of PNH that developed following a COVID-19 infection
((Albalawi M, Alwasaidi T, Almohammadi M, Alzarief AA, Elyamany G. Paroxysmal nocturnal hemoglobinuria in a patient post COVID-19 virus infection: A case report with literature review. Clin Case Rep. 2023 Oct 9;11(10):e8011. doi: 10.1002/ccr3.8011. PMID: 37822485; PMCID: PMC10562656.))
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[[PLA General Hospital of Central Theater Command]]


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[[Renmin Hospital]]
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[[Tongji Hospital]]
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[[Wuhan Union Hospital]].
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[[Zhongnan Hospital of Wuhan University]] [[China]].