====== Wortmannin ======

The aim of a [[study]] of Ji and Wang from the [[Cangzhou Central Hospital]], was to investigate the role of μ-[[opioid receptor]]s in [[acute respiratory distress syndrome]] and whether their protective effect is mediated via [[PI3K/AKT/mTOR pathway]]. What is the main finding and its importance? The findings show that activation of μ-opioid receptors ameliorates [[lung injury]], effects reversed by the PI3K inhibitor, [[wortmannin]].

The main pathology of acute respiratory distress syndrome (ARDS) is the accumulation of inflammatory cells in the [[lung]] and increased permeability of vascular [[endothelial cell]]s. The μ-opioid receptor (MOR) is a [[G protein coupled receptor]], which stimulates [[angiogenesis]] and vascular endothelial cell proliferation. In addition, MOR inhibited [[cell]] [[apoptosis]] via PI3K/Akt signaling pathway. In this study, they aimed to explore the contribution of MOR in ARDS and whether effects are mediated via PI3K/Akt signalling. An ARDS model was established by intra-tracheal instillation of 5 mg k-1 g [[lipopolysaccharide]] (LPS). Lung injury was confirmed by [[hematoxylin]] and eosin staining, lung wet/dry weight ratio, bronchoalveolar lavage fluid (BALF) protein concentrations, [[myeloperoxidase]] (MPO) activity and vascular cell adhesion molecule 1 (VCAM-1) expression. Lung inflammation was determined by assessment of [[interleukin]]-1beta (IL-1β) and tumor necrosis factor alpha (TNF-α) concentrations. The protein levels of p-Akt was detected by [[western blot]]. Endomorphin-1-activated MORs attenuated LPS-induced lung injury, lung wet/dry weight ratio, BALF protein concentrations, MPO activity, IL-1β and TNF-α levels and VCAM-1 expression, and elevated LPS-induced decreased p-Akt expression. However, the protective effect of MOR activation on lung injury was reversed by the PI3K inhibitor, wortmannin. In conclusion, μ-opioid receptor involvement in LPS-induced ARDS is via the PI3K/Akt pathway
((Ji S, Wang L. The role of μ-opioid receptors in respiratory distress syndrome 
μ-opioid receptor signalling via PI3K/Akt pathway ameliorates
lipopolysaccharide-induced acute respiratory distress syndrome. Exp Physiol. 2019
Jul 4. doi: 10.1113/EP087783. [Epub ahead of print] PubMed PMID: 31272134.
)).

===== Unclassified =====

2: Xia L, Zhu X, Zhao Y, Yang G, Zuo X, Xie P, Chen C, Han Q. Genome-wide RNA
sequencing analysis reveals that IGF-2 attenuates memory decline, oxidative
stress and amyloid plaques in an Alzheimer's disease mouse model (AD) by
activating the PI3K/AKT/CREB signaling pathway. Int Psychogeriatr. 2019 Jul
3:1-13. doi: 10.1017/S1041610219000383. [Epub ahead of print] PubMed PMID:
31266549.


3: Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, 
Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D. AT 101 induces early
mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell
death in glioma cells. Autophagy. 2018;14(10):1693-1709. doi:
10.1080/15548627.2018.1476812. Epub 2018 Jul 21. PubMed PMID: 29938581; PubMed
Central PMCID: PMC6135628.


4: Zhang W, Cui Y, Gao J, Li R, Jiang X, Tian Y, Wang K, Cui J. Recombinant
Osteopontin Improves Neurological Functional Recovery and Protects Against
Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage. Med Sci
Monit. 2018 Mar 18;24:1588-1596. PubMed PMID: 29550832; PubMed Central PMCID:
PMC5870133.


5: Guo S, Zhen Y, Wang A. Geranylgeranylacetone exerts neuroprotective roles
through medicating the phosphatidylinositol-3 kinase/Akt signaling pathway in an 
intracerebral hemorrhage rat model. Int J Neurosci. 2018 Oct;128(10):893-898.
doi: 10.1080/00207454.2017.1389925. Epub 2018 Feb 22. PubMed PMID: 29098920.


6: Pirbhoy PS, Farris S, Steward O. Synaptically driven phosphorylation of
ribosomal protein S6 is differentially regulated at active synapses versus
dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem.
2017 Jul 17;24(8):341-357. doi: 10.1101/lm.044974.117. Print 2017 Aug. PubMed
PMID: 28716954; PubMed Central PMCID: PMC5516686.


7: Wang Y, Tian Q, Liu EJ, Zhao L, Song J, Liu XA, Ren QG, Jiang X, Zeng J, Yang 
YT, Wang JZ. Activation of GSK-3 disrupts cholinergic homoeostasis in nucleus
basalis of Meynert and frontal cortex of rats. J Cell Mol Med. 2017
Dec;21(12):3515-3528. doi: 10.1111/jcmm.13262. Epub 2017 Jun 28. PubMed PMID:
28656644; PubMed Central PMCID: PMC5706587.


8: Xin JW, Jiang YG. Long non-coding RNA MALAT1 inhibits apoptosis induced by
oxygen-glucose deprivation and reoxygenation in human brain microvascular
endothelial cells. Exp Ther Med. 2017 Apr;13(4):1225-1234. doi:
10.3892/etm.2017.4095. Epub 2017 Feb 2. PubMed PMID: 28413461; PubMed Central
PMCID: PMC5377418.


9: Kawasaki Y, Fujiki M, Uchida S, Morishige M, Momii Y, Ishii K. A Single Oral
Dose of Geranylgeranylacetone Upregulates Vascular Endothelial Growth Factor and 
Protects against Kainic Acid-Induced Neuronal Cell Death: Involvement of the
Phosphatidylinositol-3 Kinase/Akt Pathway. Pathobiology. 2017;84(4):184-191. doi:
10.1159/000452862. Epub 2017 Jan 18. PubMed PMID: 28095381.


10: Lee TM, Chang NC, Lin SZ. Inhibition of infarction-induced sympathetic
innervation with endothelin receptor antagonism via a PI3K/GSK-3β-dependent
pathway. Lab Invest. 2017 Mar;97(3):243-255. doi: 10.1038/labinvest.2016.138.
Epub 2016 Dec 19. PubMed PMID: 27991911.


11: Zuo S, Ge H, Li Q, Zhang X, Hu R, Hu S, Liu X, Zhang JH, Chen Y, Feng H.
Artesunate Protected Blood-Brain Barrier via Sphingosine 1 Phosphate Receptor
1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats.
Mol Neurobiol. 2017 Mar;54(2):1213-1228. doi: 10.1007/s12035-016-9732-6. Epub
2016 Jan 28. PubMed PMID: 26820677.


12: Cui W, Zhang Y, Lu D, Ren M, Yuan G. Upregulation of p‑Akt by glial cell
line‑derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of
rats with streptozotocin‑induced diabetic encephalopathy. Mol Med Rep. 2016
Jan;13(1):543-9. doi: 10.3892/mmr.2015.4507. Epub 2015 Nov 5. PubMed PMID:
26549420.


13: Li L, Klebe D, Doycheva D, McBride DW, Krafft PR, Flores J, Zhou C, Zhang JH,
Tang J. G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition in
neonatal hypoxia-ischemia in rats. Exp Neurol. 2015 Jan;263:141-9. doi:
10.1016/j.expneurol.2014.10.004. Epub 2014 Oct 18. PubMed PMID: 25448005; PubMed 
Central PMCID: PMC4262712.


14: Lee TM, Lin SZ, Chang NC. Antiarrhythmic effect of lithium in rats after
myocardial infarction by activation of Nrf2/HO-1 signaling. Free Radic Biol Med. 
2014 Dec;77:71-81. doi: 10.1016/j.freeradbiomed.2014.08.022. Epub 2014 Sep 16.
PubMed PMID: 25224036.


15: Topkoru BC, Altay O, Duris K, Krafft PR, Yan J, Zhang JH. Nasal
administration of recombinant osteopontin attenuates early brain injury after
subarachnoid hemorrhage. Stroke. 2013 Nov;44(11):3189-94. doi:
10.1161/STROKEAHA.113.001574. Epub 2013 Sep 5. PubMed PMID: 24008574; PubMed
Central PMCID: PMC3919524.


16: Li Q, Wang F, Zhang YM, Zhou JJ, Zhang Y. Activation of cannabinoid type 2
receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis.
Cell Physiol Biochem. 2013;31(4-5):693-702. doi: 10.1159/000350088. Epub 2013 May
17. PubMed PMID: 23711495.


17: Krafft PR, Caner B, Klebe D, Rolland WB, Tang J, Zhang JH. PHA-543613
preserves blood-brain barrier integrity after intracerebral hemorrhage in mice.
Stroke. 2013 Jun;44(6):1743-7. doi: 10.1161/STROKEAHA.111.000427. Epub 2013 Apr
23. PubMed PMID: 23613493; PubMed Central PMCID: PMC3696522.


18: Zhao H, Ji Z, Tang D, Yan C, Zhao W, Gao C. Role of autophagy in early brain 
injury after subarachnoid hemorrhage in rats. Mol Biol Rep. 2013
Feb;40(2):819-27. doi: 10.1007/s11033-012-2120-z. Epub 2012 Oct 11. PubMed PMID: 
23054025.


19: Bernier LP, Blais D, Boué-Grabot É, Séguéla P. A dual polybasic motif
determines phosphoinositide binding and regulation in the P2X channel family.
PLoS One. 2012;7(7):e40595. doi: 10.1371/journal.pone.0040595. Epub 2012 Jul 11. 
PubMed PMID: 22792379; PubMed Central PMCID: PMC3394732.


20: Chen L, Zhang B, Toborek M. Autophagy is involved in nanoalumina-induced
cerebrovascular toxicity. Nanomedicine. 2013 Feb;9(2):212-21. doi:
10.1016/j.nano.2012.05.017. Epub 2012 Jun 9. PubMed PMID: 22687898; PubMed
Central PMCID: PMC3482418.


21: Bernier LP, Ase AR, Boué-Grabot E, Séguéla P. P2X4 receptor channels form
large noncytolytic pores in resting and activated microglia. Glia. 2012
May;60(5):728-37. doi: 10.1002/glia.22301. Epub 2012 Feb 8. PubMed PMID:
22318986.


22: Wang JK, Yu LN, Zhang FJ, Yang MJ, Yu J, Yan M, Chen G. Postconditioning with
sevoflurane protects against focal cerebral ischemia and reperfusion injury via
PI3K/Akt pathway. Brain Res. 2010 Oct 21;1357:142-51. doi:
10.1016/j.brainres.2010.08.009. Epub 2010 Aug 10. PubMed PMID: 20705063.


23: Fujiki M, Abe E, Nagai Y, Shiqi K, Kubo T, Ishii K, Abe T, Kobayashi H.
Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects
against cerebral infarction: Involvement of the phosphatidylinositol-3 kinase/Akt
pathway. Exp Neurol. 2010 Oct;225(2):377-83. doi:
10.1016/j.expneurol.2010.07.010. Epub 2010 Jul 21. PubMed PMID: 20654617.


24: Ase AR, Bernier LP, Blais D, Pankratov Y, Séguéla P. Modulation of
heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the
P2X1 subunit. J Neurochem. 2010 Jun;113(6):1676-84. doi:
10.1111/j.1471-4159.2010.06734.x. Epub 2010 Apr 3. PubMed PMID: 20374427.


25: Abe E, Fujiki M, Nagai Y, Shiqi K, Kubo T, Ishii K, Abe T, Kobayashi H. The
phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced 
neuroprotection against cerebral infarction in rats. Brain Res. 2010 May
12;1330:151-7. doi: 10.1016/j.brainres.2010.02.074. Epub 2010 Mar 3. PubMed PMID:
20206146.


26: Cheng G, Chunlei W, Pei W, Zhen L, Xiangzhen L. Simvastatin activates
Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after
experimental subarachnoid hemorrhage. Vascul Pharmacol. 2010
Jan-Feb;52(1-2):77-83. doi: 10.1016/j.vph.2009.12.001. Epub 2009 Dec 18. PubMed
PMID: 20004738.


27: Mo G, Bernier LP, Zhao Q, Chabot-Doré AJ, Ase AR, Logothetis D, Cao CQ,
Séguéla P. Subtype-specific regulation of P2X3 and P2X2/3 receptors by
phosphoinositides in peripheral nociceptors. Mol Pain. 2009 Aug 11;5:47. doi:
10.1186/1744-8069-5-47. PubMed PMID: 19671169; PubMed Central PMCID: PMC2734547.


28: Hai J, Lin Q, Lu Y. Phosphatidylinositol 3-kinase activity is required for
the induction of differentiation in C6 glioma cells by panaxydol. J Clin
Neurosci. 2009 Mar;16(3):444-8. doi: 10.1016/j.jocn.2008.05.014. PubMed PMID:
19179079.


29: Zhu Y, Peters C, Hallier-Neelsen M, Miller D, Pagenstecher A, Bertalanffy H, 
Sure U. Phosphatase and tensin homolog in cerebral cavernous malformation: a
potential role in pathological angiogenesis. J Neurosurg. 2009 Mar;110(3):530-9. 
doi: 10.3171/2008.7.17626. PubMed PMID: 19061355.


30: Bernier LP, Ase AR, Chevallier S, Blais D, Zhao Q, Boué-Grabot E, Logothetis 
D, Séguéla P. Phosphoinositides regulate P2X4 ATP-gated channels through direct
interactions. J Neurosci. 2008 Nov 26;28(48):12938-45. doi:
10.1523/JNEUROSCI.3038-08.2008. PubMed PMID: 19036987; PubMed Central PMCID:
PMC2628555.


31: Bernier LP, Ase AR, Tong X, Hamel E, Blais D, Zhao Q, Logothetis DE, Séguéla 
P. Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 
4,5-bisphosphate. Mol Pharmacol. 2008 Sep;74(3):785-92. doi:
10.1124/mol.108.047019. Epub 2008 Jun 3. PubMed PMID: 18523136; PubMed Central
PMCID: PMC3277329.


32: Kim SH, Munemasa Y, Kwong JM, Ahn JH, Mareninov S, Gordon LK, Caprioli J,
Piri N. Activation of autophagy in retinal ganglion cells. J Neurosci Res. 2008
Oct;86(13):2943-51. doi: 10.1002/jnr.21738. PubMed PMID: 18521932.


33: Cheung ZH, Leung MC, Yip HK, Wu W, Siu FK, So KF. A neuroprotective herbal
mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells. Cell 
Mol Neurobiol. 2008 Jan;28(1):137-55. Epub 2007 Aug 21. PubMed PMID: 17710535.


34: Marzioni M, Ueno Y, Glaser S, Francis H, Benedetti A, Alvaro D, Venter J,
Fava G, Alpini G. Cytoprotective effects of taurocholic acid feeding on the
biliary tree after adrenergic denervation of the liver. Liver Int. 2007
May;27(4):558-68. PubMed PMID: 17403196.


35: Koriyama Y, Homma K, Sugitani K, Higuchi Y, Matsukawa T, Murayama D, Kato S. 
Upregulation of IGF-I in the goldfish retinal ganglion cells during the early
stage of optic nerve regeneration. Neurochem Int. 2007 Apr;50(5):749-56. Epub
2007 Feb 8. PubMed PMID: 17363112.


36: Homma K, Koriyama Y, Mawatari K, Higuchi Y, Kosaka J, Kato S. Early
downregulation of IGF-I decides the fate of rat retinal ganglion cells after
optic nerve injury. Neurochem Int. 2007 Apr;50(5):741-8. Epub 2007 Feb 8. PubMed 
PMID: 17363111.


37: Morioka M, Kawano T, Yano S, Kai Y, Tsuiki H, Yoshinaga Y, Matsumoto J, Maeda
T, Hamada J, Yamamoto H, Fukunaga K, Kuratsu J. Hyperphosphorylation at serine
199/202 of tau factor in the gerbil hippocampus after transient forebrain
ischemia. Biochem Biophys Res Commun. 2006 Aug 18;347(1):273-8. Epub 2006 Jun 23.
PubMed PMID: 16815303.


38: Glaser S, Alvaro D, Francis H, Ueno Y, Marucci L, Benedetti A, De Morrow S,
Marzioni M, Mancino MG, Phinizy JL, Reichenbach R, Fava G, Summers R, Venter J,
Alpini G. Adrenergic receptor agonists prevent bile duct injury induced by
adrenergic denervation by increased cAMP levels and activation of Akt. Am J
Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G813-26. Epub 2005 Dec 8.
PubMed PMID: 16339297.


39: Xu XM, Zhou YQ, Wang MH. Mechanisms of cytoplasmic {beta}-catenin
accumulation and its involvement in tumorigenic activities mediated by oncogenic 
splicing variant of the receptor originated from Nantes tyrosine kinase. J Biol
Chem. 2005 Jul 1;280(26):25087-94. Epub 2005 May 6. PubMed PMID: 15878878.


40: Pezet S, Spyropoulos A, Williams RJ, McMahon SB. Activity-dependent
phosphorylation of Akt/PKB in adult DRG neurons. Eur J Neurosci. 2005
Apr;21(7):1785-97. PubMed PMID: 15869474.


41: Zubkov A, Miao L, Zhang J. Signal transduction of ET-1 in contraction of
cerebral arteries. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S24-6. PubMed
PMID: 15838290.


42: Yano S, Morioka M, Kuratsu J, Fukunaga K. Functional proteins involved in
regulation of intracellular Ca(2+) for drug development: role of
calcium/calmodulin-dependent protein kinases in ischemic neuronal death. J
Pharmacol Sci. 2005 Mar;97(3):351-4. Epub 2005 Mar 12. Review. PubMed PMID:
15764842.


43: Kilic U, Kilic E, Soliz J, Bassetti CI, Gassmann M, Hermann DM.
Erythropoietin protects from axotomy-induced degeneration of retinal ganglion
cells by activating ERK-1/-2. FASEB J. 2005 Feb;19(2):249-51. Epub 2004 Nov 19.
PubMed PMID: 15556972.


44: Kawanabe Y, Hashimoto N, Masaki T. Effects of phosphoinositide 3-kinase on
endothelin-1-induced activation of voltage-independent Ca2+ channels and
vasoconstriction. Biochem Pharmacol. 2004 Jul 15;68(2):215-21. PubMed PMID:
15193993.


45: Hashiguchi A, Yano S, Morioka M, Hamada J, Ushio Y, Takeuchi Y, Fukunaga K.
Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol
3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil 
hippocampus. J Cereb Blood Flow Metab. 2004 Mar;24(3):271-9. PubMed PMID:
15091107.


46: Cheung ZH, Chan YM, Siu FK, Yip HK, Wu W, Leung MC, So KF. Regulation of
caspase activation in axotomized retinal ganglion cells. Mol Cell Neurosci. 2004 
Mar;25(3):383-93. PubMed PMID: 15033167.


47: Kawanabe Y, Hashimoto N, Masaki T. Characterization of G proteins involved in
activation of nonselective cation channels and arachidonic acid release by
norepinephrine/alpha1A-adrenergic receptors. Am J Physiol Cell Physiol. 2004
Mar;286(3):C596-600. PubMed PMID: 14761886.


48: Reed DE, Vanner SJ. Long vasodilator reflexes projecting through the
myenteric plexus in guinea-pig ileum. J Physiol. 2003 Dec 15;553(Pt 3):911-24.
Epub 2003 Oct 10. PubMed PMID: 14555720; PubMed Central PMCID: PMC2343627.


49: Kawanabe Y, Hashimoto N, Masaki T. Effects of nonselective cation channels
and PI3K on endothelin-1-induced PYK2 tyrosine phosphorylation in C6 glioma
cells. Am J Physiol Cell Physiol. 2003 Sep;285(3):C539-45. PubMed PMID: 12900387.


50: Marzioni M, LeSage GD, Glaser S, Patel T, Marienfeld C, Ueno Y, Francis H,
Alvaro D, Tadlock L, Benedetti A, Marucci L, Baiocchi L, Phinizy JL, Alpini G.
Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile
duct-ligated rats. Am J Physiol Gastrointest Liver Physiol. 2003
May;284(5):G837-52. Epub 2003 Jan 29. PubMed PMID: 12684215.


51: Kawanabe Y, Hashimoto N, Masaki T. Involvements of voltage-independent Ca2+
channels and phosphoinositide 3-kinase in endothelin-1-induced PYK2 tyrosine
phosphorylation. Mol Pharmacol. 2003 Apr;63(4):808-13. PubMed PMID: 12644581.


52: Kawanabe Y, Hashimoto N, Masaki T. Role of phosphoinositide 3-kinase in the
nonselective cation channel activation by endothelin-1/endothelinB receptor. Am J
Physiol Cell Physiol. 2003 Feb;284(2):C506-10. PubMed PMID: 12529253.


53: Kawanabe Y, Hashimoto N, Masaki T. Effects of phosphoinositide 3-kinase on
the endothelin-1-induced activation of voltage-independent Ca(2+) channels and
mitogenesis in Chinese hamster ovary cells stably expressing endothelin(a)
receptor. Mol Pharmacol. 2002 Sep;62(3):756-61. PubMed PMID: 12181454.


54: Zhou YQ, Chen YQ, Fisher JH, Wang MH. Activation of the RON receptor tyrosine
kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2
expression in murine macrophages. J Biol Chem. 2002 Oct 11;277(41):38104-10. Epub
2002 Aug 12. PubMed PMID: 12177064.


55: Kimura H, Sasaki K, Meguro T, Zhang JH. Phosphatidylinositol 3-kinase
inhibitor failed to reduce cerebral vasospasm in dog model of experimental
subarachnoid hemorrhage. Stroke. 2002 Feb;33(2):593-9. PubMed PMID: 11823675.


56: Yano S, Morioka M, Fukunaga K, Kawano T, Hara T, Kai Y, Hamada J, Miyamoto E,
Ushio Y. Activation of Akt/protein kinase B contributes to induction of ischemic 
tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow Metab.
2001 Apr;21(4):351-60. PubMed PMID: 11323521.


57: Diem R, Meyer R, Weishaupt JH, Bahr M. Reduction of potassium currents and
phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis
factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell
death in vivo. J Neurosci. 2001 Mar 15;21(6):2058-66. PubMed PMID: 11245689.


58: Ebner S, Dunbar M, McKinnon RD. Distinct roles for PI3K in proliferation and 
survival of oligodendrocyte progenitor cells. J Neurosci Res. 2000 Nov
1;62(3):336-45. PubMed PMID: 11054802.


59: Aoki K, Zubkov AY, Parent AD, Zhang JH. Mechanism of ATP-induced [Ca(2+)](i) 
mobilization in rat basilar smooth muscle cells. Stroke. 2000 Jun;31(6):1377-84; 
discussion 1384-5. PubMed PMID: 10835460.


60: Zubkov AY, Rollins KS, Parent AD, Zhang J, Bryan RM Jr. Mechanism of
endothelin-1-induced contraction in rabbit basilar artery. Stroke. 2000
Feb;31(2):526-33. PubMed PMID: 10657432.


61: Kermer P, Klöcker N, Labes M, Bähr M. Insulin-like growth factor-I protects
axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent
Akt phosphorylation and inhibition of caspase-3 In vivo. J Neurosci. 2000 Jan
15;20(2):2-8. PubMed PMID: 10632601.


62: Zubkov AY, Ogihara K, Tumu P, Patlolla A, Lewis AI, Parent AD, Zhang J.
Mitogen-activated protein kinase mediation of hemolysate-induced contraction in
rabbit basilar artery. J Neurosurg. 1999 Jun;90(6):1091-7. PubMed PMID: 10350257.


63: Chin LS, Murray SF, Harter DH, Doherty PF, Singh SK. Sodium vanadate inhibits
apoptosis in malignant glioma cells: a role for Akt/PKB. J Biomed Sci. 1999
May-Jun;6(3):213-8. PubMed PMID: 10343170.


64: Malek AM, Jiang L, Lee I, Sessa WC, Izumo S, Alper SL. Induction of nitric
oxide synthase mRNA by shear stress requires intracellular calcium and G-protein 
signals and is modulated by PI 3 kinase. Biochem Biophys Res Commun. 1999 Jan
8;254(1):231-42. Erratum in: Biochem Biophys Res Commun 1999 Mar 5;256(1):255.
PubMed PMID: 9920763.


65: Qiu YH, Zhao X, Hayes RL, Perez-Polo JR, Pike BR, Huang L, Clifton GL, Yang
K. Activation of phosphatidylinositol 3-kinase by brain-derived neurotrophic
factor gene transfection in septo-hippocampal cultures. J Neurosci Res. 1998 Apr 
15;52(2):192-200. PubMed PMID: 9579409.