The [[Kocher]]-[[Monro]] trajectory to the cerebral [[ventricular system]] represents one of the most common [[surgical procedure]]s in the field of [[neurosurgery]]. Several studies have analyzed the specific [[white matter disruption]] produced during this [[intervention]], which has no reported adverse neurological [[outcome]]s. In a study by Pascual-Diaz et al., a graph-theoretical approach was applied to quantify the structural alterations in whole-brain level connectivity. To this end, 132 subjects were [[random]]ly selected from the [[Human Connectome Project]] [[dataset]] and used to create 3 independent 44 subjects groups. Two of the groups underwent a simulated left/right Kocher-Monro trajectory and the third was kept as a control group. For the right Kocher-Monro approach, the nodal analysis revealed decreased strength in the anterior [[cingulate gyrus]] of the transected hemisphere. The network-based statistic analysis revealed a set of right-lateralized subnetworks with decreased [[connectivity]] strength that is consistent with a subset of the [[Default Mode Network]], [[Salience Network]], and Cingulo-Opercular Network. These findings could allow for a better understanding of structural alterations caused by Kocher-Monro approaches that could reveal previously undetected clinical alterations and inform the process of designing safer and less invasive cerebral [[ventricular]] approaches
((Pascual-Diaz S, Pineda J, Serra L, Varriano F, Prats-Galino A. Default Mode
Network structural alterations in Kocher-Monro trajectory white matter
transection: A 3 and 7 tesla simulation modeling approach. PLoS One. 2019 Nov
7;14(11):e0224598. doi: 10.1371/journal.pone.0224598. eCollection 2019. PubMed
PMID: 31697747.
)).