====== Volatility ====== [[Neurosurgical guidelines]] are fundamental for evidence-based [[practice]] and have considerably increased both in number and [[content]] over the last decades. Yet, guidelines in neurosurgery are not without [[limitation]]s, as they are overwhelmingly based on low-level [[evidence]]. Such [[recommendation]]s have in the past been occasionally overturned by well-designed [[randomized controlled trial]]s (RCTs), demonstrating the [[volatility]] of poorly underpinned evidence.