====== Unruptured intracranial aneurysm (UIA) ======

see also [[International Study of Unruptured Intracranial Aneurysms]].

===== Epidemiology =====

[[Unruptured intracranial aneurysm epidemiology]].

===== Natural history =====

[[Unruptured Intracranial Aneurysm Natural History]].

===== Prevalence =====
Higher in patients with [[autosomal dominant polycystic kidney disease]] (ADPKD) or a positive family history of [[intracranial aneurysm]] or [[subarachnoid haemorrhage]] than in people without comorbidity. 

In Finland and Japan, the higher incidence of subarachnoid haemorrhage is not explained by a higher prevalence of UIAs, implicating higher risks of rupture
((Vlak MH, Algra A, Brandenburg R, Rinkel GJ. Prevalence of unruptured
intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time
period: a systematic review and meta-analysis. Lancet Neurol. 2011
Jul;10(7):626-36. doi: 10.1016/S1474-4422(11)70109-0. Review. PubMed PMID:
21641282.)).

During 1995 to 2004, a period of increasing neuroimaging utilization, Gabriel et al., did not observe an increased rate of detection of unruptured brain arteriovenous malformation (BAVM), despite increased detection of unruptured intracranial aneurysm (IA)s
((Gabriel RA, Kim H, Sidney S, McCulloch CE, Singh V, Johnston SC, Ko NU, Achrol
AS, Zaroff JG, Young WL. Ten-year detection rate of brain arteriovenous
malformations in a large, multiethnic, defined population. Stroke. 2010
Jan;41(1):21-6. doi: 10.1161/STROKEAHA.109.566018. Epub 2009 Nov 19. PubMed PMID:
19926839; PubMed Central PMCID: PMC2847493.)).


===== Etiology =====
A analysis identified differentially expressed genes and [[MicroRNA]]s in unruptured human cerebral aneurysms, suggesting the possibility of a role for MicroRNAs in aneurysm formation
((Bekelis K, Kerley-Hamilton JS, Teegarden A, Tomlinson CR, Kuintzle R, Simmons 
N, Singer RJ, Roberts DW, Kellis M, Hendrix DA. MicroRNA and gene expression
changes in unruptured human cerebral aneurysms. J Neurosurg. 2016
Dec;125(6):1390-1399. PubMed PMID: 26918470; PubMed Central PMCID: PMC5001931.
))

===== Rupture risk =====
see [[Unruptured intracranial aneurysm rupture risk]]
===== Screening =====
see [[Unruptured intracranial aneurysm screening]].

===== Clinical features =====
Most unruptured [[intracranial aneurysm]]s don’t have symptoms. “Most of these patients are found incidentally, when they get an [[MRI]] scan or [[computed tomography angiography]] scan for something unrelated.

===== Diagnosis =====

see [[Unruptured intracranial aneurysm diagnosis]].


===== Treatment =====
see [[Unruptured intracranial aneurysm treatment]].

===== Outcome =====

[[Unruptured intracranial aneurysm Outcome]].

===== Case series =====

see [[Unruptured intracranial aneurysm case series]].

===== Case reports =====

[[Unruptured intracranial aneurysm case reports]].