[[Ultraviolet B]]

In addition to [[stereotactic]] [[localization]] as well as intraoperative brain [[mapping]], techniques to enhance visual identification of tumor intraoperatively may be used and include [[5-aminolevulinic-acid]] ([[5-ALA]]). 5-ALA is metabolized into fluorescent [[porphyrin]]s, which accumulate in [[malignant glioma]] cells. These property permits use of [[ultraviolet]] illumination during surgery as an adjunct to map out the [[tumor]]. This has been proven with [[RCT]] where the use of 5-ALA leads to more complete [[resection]] (65% vs. 36%, p < 0.0001), which translates into a higher 6-month progression-free survival (41% vs. 21.1%, p = 0.0003) but no effect on OS
((Stummer W, Pichlmeier U, Meinel T, et al. Fluorescence-guided surgery with 5-aminolevu- linic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006; 7:392–401))