Systemic [[amyloidosis]] is a diseased condition where misfolded proteins deposit in various organs in the form of [[amyloid]]s, and [[transthyretin]] deposition, termed ATTR amyloidosis, can be either an age-related amyloid formation from misfolded wild-type TTR (ATTRwt) or by hereditary TTR malfunction due to mutation in the [[TTR]] gene (ATTRv). Although ATTRwt amyloidosis can cause various diseases, such as cardiac failure, conduction disturbances, [[arrhythmia]]s and [[carpal tunnel syndrome]], it is still under-recognised considering its clinical significance.