====== Trial Registries for Systematic Reviews ====== === What Are Trial Registries? === Trial registries are publicly accessible databases that list clinical trials, including ongoing, completed, and unpublished studies. Searching them helps minimize **publication bias** and identify **grey literature**. --- === Major Trial Registries to Search === * **ClinicalTrials.gov** https://clinicaltrials.gov Largest global registry maintained by the U.S. National Library of Medicine. Covers trials worldwide. * **WHO International Clinical Trials Registry Platform (ICTRP)** https://trialsearch.who.int Aggregates multiple national and regional registries into a single search portal. * **European Union Clinical Trials Register (EUCTR)** https://www.clinicaltrialsregister.eu Contains interventional clinical trials conducted in the European Union and European Economic Area. * **ISRCTN Registry** https://www.isrctn.com A primary clinical trial registry recognized by WHO and ICMJE. * **Chinese Clinical Trial Registry (ChiCTR)** http://www.chictr.org.cn Primary registry for trials conducted in China. * **Clinical Research Information Service (CRiS)** https://cris.nih.go.kr South Korean clinical trials registry. --- === How to Search Trial Registries === * Use broad keywords and synonyms related to your PICO question. * Filter by study status (e.g., recruiting, completed). * Export results where possible for screening. * Document search date, strategy, and results as part of your review. --- === Why Search Trial Registries? === * Identify unpublished or ongoing trials to reduce **publication bias**. * Access detailed protocols, sample sizes, and outcomes. * Check for **discrepancies** between registered protocols and published reports.