Many studies have proven that transient [[receptor]] potential (TRP) channels regulate the structure and function of [[mitochondria]] ---- Various human [[TRP]] channels, which are encoded by genes in multiple families, can modulate cell function by triggering a transient increase in the intracellular Ca2+ concentration ((Gees M, Colsoul B, Nilius B. The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a003962. doi: 10.1101/cshperspect.a003962. Epub 2010 Sep 22. PMID: 20861159; PMCID: PMC2944357.))